Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p019 | Stem cells and reprogramming | WCRB2014

Diabetes alters the epigenetic landscape of the oocyte and early embryo

Brown Hannah M , White Melissa A , Frank Laura A , Thompson Jeremy G

Early embryo development is an exquisitely sensitive period of the developmental continuum, profoundly influencing neonatal and adult health. Maternal and paternal hyperglycaemia is associated with long-term health complications including increased risk of miscarriage, altered birth weight, and increased incidence of diabetes and metabolic syndrome in adult life. The mechanisms underlying this intergenerational transmission of disease remain unclear. New evidence has implicate...